stage 1 lymphoma | Lyme disease-Stage 3, Stage 2 and Stage 1

Lyme disease-Stage 3, Stage 2 and Stage 1

Lyme disease is caused by Borrelia burgdorferi, a bacterium transmitted during a tick bite. The lower limbs, thighs and legs, are most affected by tick bites. But all parts of the body understood the scalp can be reached. Lyme disease evolves in several stages that differ according to each person affected. 3 more or less long stages can be observed.
Stage One
Cutaneous manifestations, called erythema migrant, EM, which most often represent the first manifestations of the disease involving more than ¾ of the infected, appear about 3 days up to one month after tick bite. Erythema begins at the spot of the tick bite and resembles a erythematous, non-painful, 5 cm macule shape that is centered at the spot of the sting. A sensation of warmth appears most often but is not accompanied by itching. This lesion can sometimes go unnoticed. A red ring often appears around the central spot.
About 20% of those affected do not have a rash and do not remember being bitten. This lesion extends rapidly after a few days but disappears in about 7 days if treatment has been prescribed avoiding complications.

The rash may be accompanied by manifestations of influenza-like illness such as fatigue, high temperature, muscle aches, headaches, shivering, arthralgia, and the presence of increased lymph gland volume Nodes
Stage 2
Symptoms likely to occur during the second stage of the disease include extreme weakness or fatigue, intense joint pain and stiffness, headaches, weakness in the facial muscles, Irritation of the eyes, rashes and an irregular heartbeat. If the disease continues to progress, it will enter a third stage.

In the abcence of treatment, Lyme disease continues to evolve and affects more and more organs. May appear, sleep disturbances, tachycardia episodes, worsening fatigue, increasingly disabling aches, pains in chewing, vision disorders, difficulty in physical exertion, Pain in the arms, back and legs, stage 3
During stage 3 of Lyme disease, which can be extended for years, the events present in Stage 2 worsen but appear in addition to many other events.
Rheumatologic Symptoms
May appear Lyme arthritis which corresponds to recurrent arthritis surges of chronic evolution.
Neurological symptoms
Can then appear after 4-6 weeks, a neuroborréliose provoking violent pain and parésthésies, most often nocturnal, occurring on nervous journeys located around the bite of the tick.
Lymphocytic meningitis can also be observed as well as an impairment of cranial nerves with peripheral facial paralysis.
This can arise from vision, orientation and concentration disorders, memory loss, aggressive episodes, and depression.
Skin Symptoms
Erythema migrant, EM, continues to evolve.
Heart Symptoms
Episodes of tachycardia and heart rate disorders can be observed.
Respiratory symptoms
Episodes of shortness of breath, oppression and coughing can also occur.
Digestive and urinary Symptoms
During this phase, it is not uncommon to see episodes of urinary tract infections, intestinal pain and diarrhea.
Rheumatologic Symptoms
Muscle aches worsen and stretch to the tendons making everyday life more and more handicapping.
Eye symptoms
Although not frequent, may occur from corneal infiltrates, anterior uveitis, or eye-motor paralysis
Tertiary stage
Skin manifestations
Skin manifestations are transformed and continue to spread and change: the skin becomes purplish or even close to a black color, oedématie and weakens to become thin and atrophied. The carractéristiques lesions of the chronic acrodermite Atrophicans or Pick-Herxheimer disease and benign cutaneous lymphoma occur.